What types of drugs cause deafness?
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- Source:Audien Hearing Aids
What types of drugs cause deafness?
Common ototoxic drugs● Aminosugar antibiotics: streptomycin, neomycin, gentamicin, amikacin, chloramphenicol, tobramycin (antibromycin myromycin), minor doxorubicin.
● Anti-tumor drugs: There are evergreens, nitroimidazole, cisplatin, nitrogen mustard, carboplatin, etc. All are ototoxic.
● Other antibiotics: chloramphenicol, erythromycin, ejaculationin, anticolin, polytycoconin B, purpotomycin, etc. Adipine, pyrimethamine.
● Synthetic antibiotics: co-trimoxazole, metronidazole, furazole.
● Antifungal drugs itraconazole, ketoconazole, etc.
● Others: indomethacin, thalidomide, aconitine, heavy metals (lead, mercury, arsenic, phosphorus, etc.). Tips:
(1) The key to preventing drug-induced deafness is the rational use of the above ototoxic drugs. Patients with a history or family history of drug-induced deafness should avoid using these drugs.
(2) When applying deafness drugs, the inner ear must be protected. At the same time, vitamin B1, vitamin B2, vitamin C, calcium pantothenate or anti-allergic drugs can have a certain protective effect on the inner ear.
(3) Avoid combined or continuous application of multiple ototoxic drugs. When aminoglycoside antibiotics are used together with diuretics, or several aminoglycoside antibiotics are used together, the deafening effect will be significantly increased, and the indications should be understood when combined use is required.
(4) When using ototoxic drugs, patients should be alert to the early symptoms of poisoning, such as high-pitched tinnitus, ear swelling, deafness, dizziness, nausea and other symptoms, and the drug should be discontinued in time.
Deafness caused by ototoxic drugs is caused by direct damage to the sensory nerve cells of the inner ear. Once the nerve cells of the human body die, it is difficult to regenerate. Therefore, it has not yet been discovered. Find effective treatments. Timely detection, early diagnosis and early intervention are required.
The task of prevention is very arduous. First of all, the indications for the use of ototoxic drugs should be strictly controlled. Children should try to avoid or not use streptomycin and gentamicin; secondly, hearing should be strictly tested during the application process. Ear drops formulated with aminoglycoside antibiotics are prohibited.
Once signs of drug poisoning occur, such as deafness, tinnitus, nausea, vomiting, dizziness, skin numbness, etc., the drug should be discontinued in time. Another ototoxic drug cannot be used to replace the original drug to continue treatment, nor can more than two ototoxic drugs be used interchangeably.